Selenoprotein P protects cells from lipid hydroperoxides generated by 15-LOX-1
نویسندگان
چکیده
منابع مشابه
Is 15-LOX-1 a tumor suppressor?
A number of enzymes in the cyclooxygenase and lipoxygenase pathways process fatty acids to generate a variety of bioactive lipids. Recent findings that link inflammation to carcinogenesis have started to reveal how these bioactive lipids function in cellular signaling pathways as lipid messengers that mediate responses to cellular injury through inflammatory processes (1). Downstream effects of...
متن کاملSEPP 1 ( selenoprotein P , plasma , 1 )
Note SEPP1 belongs to selenoproteins, all of which contain selenium in the form of selenocysteine (SeC) and are being synthesized in the presence of UGA codon, specific stem loop structure in 3' UTR of mRNA called SECIS (Selenocysteine Insertion Sequence) and other specific factors. Selenoprotein P is a glycoprotein present mainly in plasma, where it accounts for 40 65% of total selenium in thi...
متن کاملLipid hydroperoxides in plants.
Hydroperoxides are the primary oxygenated products of polyunsaturated fatty acids and were determined spectrophotometrically based on their reaction with an excess of Fe2+ at low pH in the presence of the dye Xylenol Orange. Triphenylphosphine-mediated hydroxide formation was used to authenticate the signal generated by the hydroperoxides. The method readily detected lipid peroxidation in a ran...
متن کاملEnhanced glutathione peroxidase expression protects cells from hydroperoxides but not from radiation or doxorubicin.
Both radiation and anthracycline antibiotics may produce reactive oxygen species to cause cytotoxicity, and it has been suggested that some cellular antioxidant enzymes may be important for resistance to these agents. The human breast adenocarcinoma cell line MCF-7WT has a low level of glutathione peroxidase (GPX) activity. We have transfected MCF-7WT cells with a plasmid that contains the cDNA...
متن کاملPreparation of pure lipid hydroperoxides.
Increasing evidence of lipid peroxidation in food deterioration and pathophysiology of diseases have revealed the need for a pure lipid hydroperoxide (LOOH) reference as an authentic standard for quantification and as a compound for biological studies in this field. Generally, LOOH is prepared from photo- or enzymatically oxidized lipids; however, separating LOOH from other oxidation products a...
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ژورنال
عنوان ژورنال: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
سال: 2010
ISSN: 0952-3278
DOI: 10.1016/j.plefa.2010.08.006